Progerin is the malformed version of LMNA, a protein vital to the structure of the cell nucleus. It is the cause of progeria, a rare condition that has the superficial appearance of greatly accelerated aging. It isn’t aging, however, but rather an enormous burden of cellular damage and dysfunction resulting from structural issues in the cell nucleus that affect near all forms of function. In normal aging, there is also an enormous burden of damage and dysfunction, but this arises from a completely different mix of issues. Some of the end results, such as cardiovascular disease, are somewhat similar, but one can’t compare the two if interested in first causes. In the case of patients with progeria, the LMNA gene is mutated, resulting in large amounts of
From https://heidifrost.blogspot.com/2019/05/increased-levels-of-progerin-observed.html
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https://heidifrost0.wordpress.com/2019/05/04/increased-levels-of-progerin-observed-in-overweight-individuals/
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