Presenting the SASP Atlas for the Senescence-Associated Secretory Phenotype

The presence of growing numbers of lingering senescent cells is one of the root causes of aging. Vast numbers of cells become senescent every day, but near all are quickly removed, either via programmed cell death or the actions of the immune system. A tiny number survive, however, and that alone would eventually be enough to cause age-related disease and death. While senescent cells never rise to very large fractions of all of the cells in a given tissue, they cause considerable harm via a potent mix of secreted signals known as the senescence-associated secretory phenotype, or SASP. The SASP causes chronic inflammation and destructive remodeling of the nearby extracellular matrix. Further, it changes the behavior of other cells for the worse, including increasing their

From https://www.fightaging.org/archives/2019/05/presenting-the-sasp-atlas-for-the-senescence-associated-secretory-phenotype/

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From https://heidifrost.blogspot.com/2019/05/presenting-sasp-atlas-for-senescence.html

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